Home Transmembrane Transporters -Neuronal Signaling P-gp

P-gp

P-gp Products

  • All (17)
  • P-gp Inhibitors (12)
  • P-gp Agonist (1)
  • P-gp Modulators (4)
  • New P-gp Products
Catalog No. Product Name Information Product Use Citations Product Validations
S8028 Tariquidar Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.
Biomol Ther (Seoul), 2025, 33(1):170-181
Drug Resist Updat, 2024, 73:101066
Front Pharmacol, 2024, 15:1477318
S1481 Zosuquidar 3HCl Zosuquidar 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.
Hepatol Commun, 2024, 8(5)e0437
Adv Healthc Mater, 2022, e2201984
Mol Cancer Ther, 2022, 21 (7): 1227–1235.
S4202 Verapamil HCl Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
J Immunother Cancer, 2024, 12(11)e009805
NPJ Precis Oncol, 2024, 8(1):94
Int J Mol Sci, 2024, 25(18)10162
S7772 Elacridar (GF120918) Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.
Int J Mol Sci, 2025, 26(3)1124
Cell Death Dis, 2024, 15(8):558
Oncogene, 2024, 43(26):2038-2050
S7124 SC144 SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.
bioRxiv, 2025, 2025.01.20.633954
Nat Med, 2024, 30(6):1696-1710
Nat Med, 2024, 10.1038/s41591-024-02953-4
S4662 Atazanavir Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.
Int J Mol Sci, 2022, 23(23)15380
Chemistry, 2022, e202202798.
Cells, 2021, 10(12)3458
S9145 Solamargine Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.
Sci Rep, 2016, 6:36721
S3235 Sinapine Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.
Gene, 2022, 827:146460
S0921 Wilforine Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
S3431 Encequidar (HM30181) Encequidar (HM30181, HM30181A) is a potent and selective inhibitor of the adenosine triphosphate-binding cassette transporter P-glycoprotein (P-gp).
E1781 Biricodar Biricodar(VX-710) is a modulator of P-glycoprotein and MRP-1 with minimal in vivo toxicity. It enhances the effectiveness of various antibiotics against numerous gram-positive pathogens and exhibits potent chemosensitizing properties in cells resistant to multiple drugs.
S3600 Schisandrin B Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.
Drug Des Devel Ther, 2024, 18:4241-4256
Viruses, 2022, 14(2)353
Pharmacol Res, 2021, 166:105459
S4746 (20S)-Protopanaxadiol 20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.
E0080 UCLA GP130 2 UCLA GP130 2 (GP130 receptor agonist-1) is a potent, brain-penetrant and orally active Glycoprotein 130 (Gp130) receptor agonist, being a humanin mimetic binding to the GP130 D4-D5 domain and reducing NMDA-induced toxicity.
S9201 Levistilide A Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.
S9563 Evodine Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. Evodine is a potent P-gp inhibitor.
E1742 Reversan Reversan (CBLC4H10) is a selective and nontoxic inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp), with the potential to treat neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
S8028 Tariquidar Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.
Biomol Ther (Seoul), 2025, 33(1):170-181
Drug Resist Updat, 2024, 73:101066
Front Pharmacol, 2024, 15:1477318
S4202 Verapamil HCl Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
J Immunother Cancer, 2024, 12(11)e009805
NPJ Precis Oncol, 2024, 8(1):94
Int J Mol Sci, 2024, 25(18)10162
S7772 Elacridar (GF120918) Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.
Int J Mol Sci, 2025, 26(3)1124
Cell Death Dis, 2024, 15(8):558
Oncogene, 2024, 43(26):2038-2050
S7124 SC144 SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.
bioRxiv, 2025, 2025.01.20.633954
Nat Med, 2024, 30(6):1696-1710
Nat Med, 2024, 10.1038/s41591-024-02953-4
S9145 Solamargine Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.
Sci Rep, 2016, 6:36721
S3235 Sinapine Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.
Gene, 2022, 827:146460
S0921 Wilforine Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
S3431 Encequidar (HM30181) Encequidar (HM30181, HM30181A) is a potent and selective inhibitor of the adenosine triphosphate-binding cassette transporter P-glycoprotein (P-gp).
S3600 Schisandrin B Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.
Drug Des Devel Ther, 2024, 18:4241-4256
Viruses, 2022, 14(2)353
Pharmacol Res, 2021, 166:105459
S4746 (20S)-Protopanaxadiol 20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.
S9563 Evodine Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. Evodine is a potent P-gp inhibitor.
E1742 Reversan Reversan (CBLC4H10) is a selective and nontoxic inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp), with the potential to treat neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
E0080 UCLA GP130 2 UCLA GP130 2 (GP130 receptor agonist-1) is a potent, brain-penetrant and orally active Glycoprotein 130 (Gp130) receptor agonist, being a humanin mimetic binding to the GP130 D4-D5 domain and reducing NMDA-induced toxicity.
S1481 Zosuquidar 3HCl Zosuquidar 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.
Hepatol Commun, 2024, 8(5)e0437
Adv Healthc Mater, 2022, e2201984
Mol Cancer Ther, 2022, 21 (7): 1227–1235.
S4662 Atazanavir Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.
Int J Mol Sci, 2022, 23(23)15380
Chemistry, 2022, e202202798.
Cells, 2021, 10(12)3458
E1781 Biricodar Biricodar(VX-710) is a modulator of P-glycoprotein and MRP-1 with minimal in vivo toxicity. It enhances the effectiveness of various antibiotics against numerous gram-positive pathogens and exhibits potent chemosensitizing properties in cells resistant to multiple drugs.
S9201 Levistilide A Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.

Choose Selective P-gp Inhibitors

P-gpSignaling Pathway

P-gp信号通路图
Tags: P-gp inhibitor|P-gp agonist|P-gp activator|P-gp inducer|P-gp antagonist|P-gp signaling pathway|P-gp assay kit